In this podcast co-sponsered by the ATS RCMB Early Career Professionals Working Group and the Web Committee, Dr. Rachel Knipe (MGH) interviews Dr. Amanda Tatler (Nottingham), Dr. Fransesca Polverino (Arizona), Dr. Marta Bueno (Pitt), Dr. Maria Basil (UPenn), Dr. Josh Englert (Ohio State) and Dr. Chris Pascoe (Manitoba). This group of young physician-scientists discusses the challenges that have arisen in their careers during the last 6 months as things were interrupted by the COVID-19 pandemic surge. The discussion addresses obstacles they have faced, things that have helped, and fears that they all share for the future. We suspect many of the sentiments raised in this podcast are shared across the world throughout academic institutions and hope to provide some assurance that others are going through similar struggles, and encourage discussions around supports that can help this vulnerable group of scientists.