In this “Breathe Easy Critical Perspective” podcast, Dr. Dominique Pepper interviews Drs. Jehan Alladina and Corey Hardin. They discuss the respiratory physiology of mechanically ventilated patients with COVID-19. Dr. Alladina and Hardin are pulmonary and critical care physicians at Massachusetts General Hospital (MGH) in Boston, MA. Dr. Hardin is also the Assistant Directory of the Cardiopulmonary Exercise Laboratory at MGH.