In this “Breathe Easy Critical Perspective” podcast, Dr. Dominique Pepper interviews Drs. Bruno Ferreyro and Federico Angriman . They discuss the role of non-invasive ventilation for acute hypoxemic respiratory failure, published online June 4, 2020 by JAMA. Drs. Ferreyro and Angriman are affiliated with the Interdepartmental Division of Critical Care Medicine at the University of Toronto, Ontario Canada.