In this “Breathe Easy Critical Perspective” podcast, Dr. Dominique Pepper interviews Dr. Dharshi Karalapillai. They discuss the trial published in JAMA (September 2020) that investigated the effect of low versus conventional tidal volumes during operative procedures. Dr. Karalapillai is a dual-trained anesthetist and Intensive care physician. He is a Staff Intensivist and a Visiting Anesthetist at Austin Health, Australia.