In this “Breathe Easy Critical Perspective” podcast, Dr. Dominique Pepper interviews Dr. Luciano Azevedo. They discuss the CoDEX trial published in JAMA that investigated the effect of dexamethasone in moderate or severe ARDS due to COVID-19. Dr. Azevedo is a professor at the Emergency Medicine Department at the University of São Paulo and the coordinator of the Intensive Care and Anesthesiology Experimental Laboratory at the Instituto Sirio-Libanes de Ensino e Pesquisa in São Paulo.