In the past 20 years, human genetics and genomics research has boomed and given us novel insights into the nature of human disease. Despite this explosion the field is technically and analytically challenging but at the same time rapidly changing and evolving. This leaves many of us wondering, "How does one develop and sustain a successful career in human genomics?" Drs. Blanca Himes and Craig Hersh share their insights and advice on how to start your career in respiratory genomics.